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Duke University Health System Launches OneDukeGen, a New Precision Medicine Study

The Duke University Health System and School of Medicine are launching OneDukeGen, a precision medicine study that will advance healthcare through cutting-edge research and collaboration. In a partnership with nference, OneDukeGen will embark on a journey to unravel the intricate connections between genetics, health, and disease. 

OneDukeGen will integrate comprehensive genomic data and health information to foster a deep understanding of hereditary disease susceptibilities. Led by Principal Investigator Svati Shah, MD, MHS, Associate Dean of Genomics, the study aims to exclusively recruit over 100,000 consented Duke patients to participate in this pivotal research. 

The study is committed to ensuring representation of diverse populations as well as equitable return of genetic sequencing results in research. The design of OneDukeGen is deeply rooted in inclusivity and was formed by incorporating a diverse range of perspectives gained from engaging community groups.  

Our collaborative approach brings together Duke researchers and clinicians who will work in tandem to integrate research findings into patient care. This synergy is the hallmark of precision medicine – a dynamic field that tailors medical interventions to individual characteristics, including genetics. By bridging the gap between scientific discovery and clinical practice, we are poised to usher in a new era of healthcare delivery. 

This effort will fuel scientific discovery and facilitate insights that can potentially revolutionize our understanding of disease. Together, we are charting a path towards a healthier and more informed future. 

Visit to learn more about the OneDukeGen study and how Duke patients will be invited to participate.