The U.S. Department of Health and Human Services (HHS) has issued a sweeping Request for Information (RFI) to identify how artificial intelligence (AI) can accelerate clinical transformation across the American healthcare system. Framed as a call to harness AI for lower costs and improved care, the initiative invites input on everything from evolving reimbursement frameworks to rethinking regulatory pathways. But beneath the enthusiasm lies a complex set of operational, legal, and ethical dynamics that will shape whether these ambitions translate into scalable realities.

A newly unsealed federal indictment against a Los Angeles-area physician alleges a $45 million Medicare fraud scheme involving falsified Botox claims, exposing once again the operational vulnerabilities that continue to undermine the integrity of federal health programs. The charges against Dr. Violetta Mailyan include wire fraud and obstruction of justice, centered on billing for procedures that were medically unnecessary or never performed. While the case is still pending, it signals ongoing systemic exposure to high-value, low-detection fraud.

Jasmine Harris, Contributing Editor Mount Sinai Health System’s recognition in the 2025 CHIME Digital Health Most Wired survey affirms its leadership in digital transformation—but the Level 9 designation also reflects something more consequential: a shift from digital enablement to digital fluency. With advanced analytics, ambient clinical AI, and patient-facing virtual tools now operationalized across the enterprise, Mount Sinai offers a working model for how health systems can architect digital strategies that are scalable, safe, and sustainable.

The Centers for Medicare & Medicaid Services (CMS) has proposed a new mandatory payment model aimed at lowering prescription drug costs for Medicare beneficiaries, a move that underscores both the urgency and complexity of reforming drug pricing in the United States. Dubbed the Guarding U.S. Medicare Against Rising Drug Costs (GUARD) Model, the initiative introduces international price benchmarking and modified rebate structures to rein in spending under Medicare Part D. But while the model reflects an aggressive policy posture, it also raises significant implementation and equity questions as it moves toward a 2027 launch.