The U.S. Department of Health and Human Services (HHS) has issued a sweeping Request for Information (RFI) to identify how artificial intelligence (AI) can accelerate clinical transformation across the American healthcare system. Framed as a call to harness AI for lower costs and improved care, the initiative invites input on everything from evolving reimbursement frameworks to rethinking regulatory pathways. But beneath the enthusiasm lies a complex set of operational, legal, and ethical dynamics that will shape whether these ambitions translate into scalable realities.

A newly unsealed federal indictment against a Los Angeles-area physician alleges a $45 million Medicare fraud scheme involving falsified Botox claims, exposing once again the operational vulnerabilities that continue to undermine the integrity of federal health programs. The charges against Dr. Violetta Mailyan include wire fraud and obstruction of justice, centered on billing for procedures that were medically unnecessary or never performed. While the case is still pending, it signals ongoing systemic exposure to high-value, low-detection fraud.

The Centers for Medicare & Medicaid Services (CMS) has proposed a new mandatory payment model aimed at lowering prescription drug costs for Medicare beneficiaries, a move that underscores both the urgency and complexity of reforming drug pricing in the United States. Dubbed the Guarding U.S. Medicare Against Rising Drug Costs (GUARD) Model, the initiative introduces international price benchmarking and modified rebate structures to rein in spending under Medicare Part D. But while the model reflects an aggressive policy posture, it also raises significant implementation and equity questions as it moves toward a 2027 launch.

The criminal convictions of three former executives at Magellan Diagnostics mark more than the end of a federal case. They spotlight a fundamental breakdown in how health IT tools are regulated, trusted, and used to guide clinical decisions. From 2013 to 2017, Magellan’s LeadCare II device accounted for the majority of pediatric lead screenings in the United States.

The U.S. Department of Health and Human Services (HHS) has released its first unified artificial intelligence (AI) strategy, positioning AI as a transformative tool for internal operations, public health research, and care modernization. Framed as a “OneHHS” approach, the strategy invites coordination across all departmental divisions, including CDC, CMS, FDA, and NIH.

The Office of the National Coordinator for Health IT (ONC), in coordination with the Assistant Secretary for Technology Policy (ASTP), announced temporary enforcement discretion for certain compliance and attestation deadlines within the ONC Health IT Certification Program. While positioned as a procedural adjustment due to a lapse in federal appropriations, the decision reveals a deeper structural concern: the fragility of public-sector infrastructure that underpins regulatory accountability in health IT.

The Centers for Medicare & Medicaid Services (CMS) has now completed its second cycle of negotiated pricing under the Inflation Reduction Act, and the numbers are no longer theoretical. Had the 2027 negotiated prices been in effect this year, CMS estimates Medicare would have saved $12 billion across just 15 drugs—a 44% reduction in net spending. The implications for payers, health systems, pharmacy benefit managers, and formulary design are immediate and structural.

With the launch of the Genesis Mission through a sweeping Executive Order on November 24, 2025, the United States has declared a full-scale national effort to integrate artificial intelligence into the heart of federal science, security, and innovation policy. Drawing parallels to the Manhattan Project, the order does not simply accelerate AI research. It also formalizes a new governance model for high-performance computing, secure data infrastructure, and AI-directed experimentation.